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Anti-CDK2 staining (n = 5) of (a) wildtype (SGPL+/+) and (b) SGPL1 knockout (SGPL−/−) colon sections and (c) SGPL1 knockout colon tumor sections after CAC induction (9 weeks); (magnification 40×). (d) Overview of CDK2 protein distribution during cell phases (scheme on the basis of [17]); CAC = colitis associated colon cancer; in image: t = Crypt tip; b = crypt bottom.
