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. 2021 May 25;22(11):5623. doi: 10.3390/ijms22115623

Figure 3.

Figure 3

Interaction between subchronic (for 7 days) administration of therapeutic-relevant concentration of VPA (500 μM) and antipsychotics, CLZ (A), QTP (B) and BPZ (C) on l-glutamate release through activated hemichannel. Ordinate: mean ± SD (n = 6) of the FCHK-evoked astroglial l-glutamate release (μM), and abscissa: concentration of CLZ, QTP and BPZ (μM). Black and blue circles indicate acute antipsychotics administration alone (control) and combination of subchronic administration of VPA with antipsychotics (+VPA), respectively. * p < 0.05, ** p < 0.01: relative to antipsychotics free, @@ p < 0.01: relative to control by MANOVA with Tukey’s post hoc test.