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. 2021 May 28;13(11):2674. doi: 10.3390/cancers13112674

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The correlation between c-Met targeted fluorescence and immunohistochemistry. Overview of imaging and pathological assessment of three different samples showing ex vivo white light, Cy5-based fluorescence imaging of the incubated tissue (fluorescence in red), real-time image processing of the fluorescence signal (including video representation of tumor-to-background ratio (TBR)), H&E staining and c-MET immunohistochemistry. (A) superficial tumor localization, (B) tumor presence on the cleavage plane and (C) a sample without tumor presence on the cleavage plane. Delineation of the tumor (dashed) was based on H&E.