Table 1.
List of experimental evidence summarizing the role of neurotrophins in the modulation of cholesterol metabolism. ↑ indicate an increase; ↓ indicates a decrease.
| Neurotrophin/Receptor | Cell Context | Effects | References |
|---|---|---|---|
| NGF | PC12 cell line | ↑ HMGCR activity | [239] |
| NGF/TrkA | PC12 cell line | ↑ apoER2 proteolytic processing ↑ apoE transcription |
[244,245] |
| GT1–1 Trk cell line; PC12 cell line |
↑ LRP1 endocytic activity ↑ LRP1 mRNA levels |
[240,241] | |
| NGF/TrkA pro-NGF/p75NTR pro-BDNF/p75NTR |
PC6.3 cell line; Cultured septal neurons from embryonic rat brain |
↑ LDLr expression ↑ Lipoprotein uptake |
[242] |
| NGF/p75NTR | PC12 cell line | ↑ Cholesterogenic enzymes | [246] |
| NGF/p75NTR pro-NGF/p75NTR |
Huh7 hepatocyte cells | ↑ Lipid- and cholesterol-associated proteins | [247,248] |
| BDNF/TrkB | Cerebral cortex; Hippocampal neurons from embryonic rats |
↑ hmgcr and mpd transcripts | [188] |
| NHA cells U87 MG cell line |
↑ apoE biosynthesis; ↑ ABCA1 levels; ↑ Cholesterol efflux; |
[30] | |
| SH-SY5Y cell line | ↑ hmgcr mRNA levels; ↓ Extracellular cholesterol uptake |
[30] | |
| p75NTR | Neuro2a cell line; Primary cerebellar neuronal cultures |
↑ hmgcr and dhcr7 | [249] |
| NRIF/p75NTR | Neuro2a cell line | ↑ Cholesterogenic enzymes | [250] |