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. 2021 May 30;22(11):5884. doi: 10.3390/ijms22115884

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Lipid profile and lipid changes of HepaRG cells. (A) The annotated lipids found in the HepaRG cells using the MS-DIAL lipidomics database, including about 4000 lipids in 23 lipid subclasses; (B) Visual plot of the metabolic network of palmitic acid in the glycerophospholipid pathway in untreated cells, drawn using Cytoscape software (n = 5); (C) Visual plot of the changes in the content of differential lipids involved in the metabolic network of palmitic acid in cells administered 0.2 mM palmitic acid for 24 h (n = 5); (D) Visual plot of the content changes in cells administered 0.2 mM palmitic acid plus 0.25 mM magnesium isoglycyrrhizinate (MGIG) for 24 h (n = 5). Acar: Acyl Carnitine; CE: Cholesterol ester; DGDG: Digalactosyldiacylglycerol; FA: Free Fatty acids; FAHFA: Fatty acid esters of hydroxy fatty acids; TAG: Triglyceride; DAG: Diglyceride; MAG: Monoglycerides; CL: Bisphosphatidylglycerol; PA: Phosphatidic acid; LPA: Lysophosphatidic acid; PC: Phosphatidylcholine; LPC: Lysophosphatidylcholine; PE: phosphatidylethanolamine; LPE: Lysophosphatidylethanolamine; PG: Phosphatidylglycerol; LPG: Lysophosphatidylglycerol; PI: Phosphatidylinositol; LPI: Lysophosphatidylinositol; PS: Phosphatidylserine; LPS: Lysophosphatidylserine; SM: Sphingomyelin; Sph: Sphingosine.