Figure 1.

The leading causes of obesity and aging are driven by adipose tissue distribution, function, and environment. Contributions of the central nervous system (CNS), sexual dimorphism, diet, life style, and adipose tissue distribution to obesity and aging are well known. In addition, the composition of adipose tissue itself with increased collagen, extra cellular matrix (ECM), reactive oxygen species (ROS), immune cells, macrophages, and senescent cells is another major contributor to obesity and aging. Furthermore, the functionality of mitochondria and endoplasmic reticulum (ER) in adipocytes plays an important role in preventing obesity and aging complications. Figure created with ©BioRender.io.