Table 1.
Univariate and multivariate analyses of the association between prognostic variables and disease-free survival rates in epithelial ovarian cancer.
| Variables | Univariate Analysis | Multivariate Analysis | ||
|---|---|---|---|---|
| Hazard Ratio [95%CI *] | p-Value | Hazard Ratio [95%CI *] | p-Value | |
| FIGO stage (III-IV) | 6.427 [3.335–12.386] | <0.001 | 4.604 [2.260–9.380] | <0.001 |
| Cell type (Serous) | 0.337 [0.202–0.561] | <0.001 | 0.525 [0.294–0.939] | 0.030 |
| Tumor grade (Poor) | 1.949 [1.286–2.954] | 0.002 | 1.646 [1.074–2.518] | 0.022 |
| CA 125 + (>35 U/mL) | 2.397 [1.208–4.753] | 0.012 | 1.004 [0.471–2.141] | 0.992 |
| Age (>50) | 1.577 [1.064–2.339] | 0.023 | 1.231 [0.810–1.872] | 0.330 |
| ERα + a | 1.625 [1.038–2.542] | 0.034 | 1.363 [0.842–2.207] | 0.207 |
| AR + b | 1.887 [1.245–2.860] | 0.002 | 1.546 [0.998–2.396] | 0.051 |
| PR + c | 1.201 [0.794–1.815] | 0.386 | NA | |
| GR + d | 2.610 [1.143–5.958] | 0.023 | 1.892 [0.823–4.351] | 0.133 |
| ERβ + e | 1.824 [1.226–2.714] | 0.003 | 1.403 [0.918–2.543] | 0.118 |
| Heatmap (Triple dominant) |
2.668 [1.728–4.118] | <0.001 | 2.176 [1.361–3.487] | 0.001 |
a cut-off value of ERα is over 49.2 of IHC score; b cut-off value of AR is over 10.85 of IHC score; c cut-off value of PR is over 21.18 of IHC score; d cut-off value of GR is over 8.65 of IHC score; e cut-off value of ERβ is over 105.97 of IHC score; * CI, confidence interval; FIGO, International Federation of Gynecology and Obstetrics; NA: Not available.