Figure 1.

Expression of PDIA1 in myeloma associates with survival. CD138-purified myeloma cells from patients with multiple myeloma were subjected to RNA sequencing and survival was estimated based on Kaplan–Meier for low, medium, and high PDIA1 expression tertiles. The statistical significance for the survival curves was determined by Log-rank test. (A) High and medium expression resulted in inferior survival in the entire myeloma cohort. While (B) no significant effect on survival was seen in newly diagnosed myeloma, in (C) patients with early (1–3 prior lines of therapy) or (D) late relapse (>3 prior lines of therapy) medium and high PDIA1 expression tertile were associated with shorter survival. Abbreviations: NDMM—newly diagnosed multiple myeloma; ERMM—early relapse multiple myeloma; LRMM—late relapse multiple myeloma; os—overall survival.