Figure 6.

The onco-suppressive role of two circRNAs in bladder cancer. circ-FNDC3B sponges miR-1178-3p, preventing its binding to the 5′ untranslated region (UTR) of G3BP2, hence reducing G3BP2 translation and, consequently, inhibiting the activation of FAK/SRC-mediated signaling. Similarly, circ-PICALM sponges miR-1265 and prevents it from binding to the 3′ UTR of STEAP4, this way mediating its upregulation. Thus, STEAP4 binds to FAK and inhibits its phosphorylation, leading to cancer repression. Red “reverse tau” symbols (⊥) indicate attenuation of expression, whereas green arrows denote induction of expression. Blue arrows indicate the sequence of events, while vertical grey arrows indicate decreased expression levels. Τhe parallel red lines (//) indicate the inhibition of an effect.