Table 1.

circRNAs with a regulatory effect in cancer progression through the VEGF and WNT/β-catenin signaling pathways.

Pathway	Cancer	circRNA	Gene of Origin	Interactions	Effect	Reference
VEGF	Bladder cancer	circ-MYLK	MYLK	miR-29a-3p/VEGFA	Promotes cancer progression	[43]
	Cervical cancer	circ_0023404	RNF121	miR-5047/VEGFA	Promotes cancer metastasis and chemoresistance	[46]
	Colorectal cancer	circ_001971 (circ_0001060) 1	UXS1	miR-29c-3p/VEGFA	Promotes cancer growth, angiogenesis, and metastasis	[47]
	Renal cell carcinoma	circ-MYLK	MYLK	miR-513a-5p/VEGFC	Promotes cancer growth and metastasis	[44]
	Pancreatic cancer	circ-NFIB1 (circ_0086375) 1	NFIB	miR-486-5p/ PIK3R1/VEGFC	Inhibits lymphangiogenesis and lymphatic metastasis, suppresses cancer progression	[45]
WNT/β-catenin	Glioblastoma multiforme	circ_0043278	TADA2A	miR-638	Promotes cancer progression	[50]
	Osteosarcoma	circ-MYO10	MYO10	miR-370-3p/RUVBL1	Regulates chromatin remodeling; promotes cancer progression	[51]
		circ_0002052	PAPPA	miR-1205/APC2	Suppresses cancer progression	[52]
	Papillary thyroid cancer	circ_102171	SMURF2	CTNNBIP1	Promotes cancer progression	[53]
		circ-ITCH	ITCH	miR-22-3p/CBL	Suppresses cancer progression	[54]
	Breast cancer	circ-ITCH	ITCH	miR-214-3p/ITCH, miR-17-5p/ITCH	Suppresses cancer progression	[55]
	Endometrial	circ_0002577	WDR26	miR-197-3p/CTNND1	Promotes cancer progression	[56]
	Esophageal squamous cell carcinoma	circ-GSK3B	GSK3B	-	Promotes metastasis	[57]
	Colorectal cancer	circ_100290	-	miR-516b-5p/FZD4	Promotes cancer progression	[58]
		circ_0009361	GNB1	miR-582-3p/APC2	Suppresses cancer progression	[59]
	Gastric cancer	circ-HECTD1	HECTD1	miR-1256	Promotes glutaminolysis and cancer progression	[60]
		circ-HIPK3	HIPK3	WNT1, TCF4, β-catenin	Promotes cancer progression	[20]
		circ-FGD4	FGD4	miR-532-3p/APC	Suppresses cancer progression	[61]
		circ-REPS2	REPS2	miR-558/RUNX3		[62]
	Hepatocellular carcinoma	circ-ZFR	ZFR	miR-3619-5p/β-catenin	Promotes cancer progression	[63]
		circ_0067934	PRKCI	miR-1324/FZD5	Promotes tumor growth and metastasis	[64]
	Lung cancer	circ_0006427	BCAR3	miR-6783-3p/DKK1	Suppresses cancer progression	[65]
	Non-small cell lung cancer	circ_000984 (circ_0001724) 1	CDK6	-	Promotes cell proliferation and metastasis	[66]
	Retinoblastoma	circ-TET1	TET1	miR-492, miR-494-3p	Suppresses cancer progression	[67]

¹ Names in parentheses denote the circRNA ID or alias, as listed on circBase.