Table 3.
circRNAs with a regulatory effect in cancer progression through the PI3K/AKT signaling pathway.
| Cancer | circRNA | Gene of Origin | Interactions | Effect | Reference |
|---|---|---|---|---|---|
| Glioma | circ_0015758 | CFH | miR-149-3p/AKT1 | Promotes cancer progression | [97] |
| circ_0037655 | CREBBP | miR-214-3p/PI3K | [102] | ||
| circ_0014359 | NUP210L | miR-153-3p | [103] | ||
| Glioblastoma | circ_0067934 | PRKCI | - | Promotes cancer progression | [104] |
| Osteosarcoma | circ_0102049 | ATL1 | miR-1304-5p/MDM2 | Promotes cancer progression | [99] |
| Laryngeal squamous cell carcinoma | circ-PARD3 | PARD3 | miR-145-5p/ PRKCI/AKT1/MTOR |
Promotes cancer progression | [96] |
| Thyroid Carcinoma | circ_0067934 | PRKCI | - | Promotes cancer progression | [105] |
| Papillary thyroid carcinoma | circ-PSD3 | PSD3 | miR-637/HEMGN | Promotes cancer progression | [106] |
| circ_0039411 | MMP2 | miR-1179/ABCA9, miR-1205/MTA1 | Promotes cancer progression | [100] | |
| Breast cancer | circ_103809 | - | Promotes cancer progression | [107] | |
| circ_001569 (circ_0000677) 1 |
ABCC1 | - | [108] | ||
| Ovarian cancer | circ-FAM53B | FAM53B | miR-646/VAMP2, miR-647/MDM2 |
Promotes cancer progression | [98] |
| circ-RHOBTB3 | RHOBTB3 | - | Suppresses cancer progression | [109] | |
| Endometrial cancer | circ_0002577 | WDR26 | IGF1R/PI3K/AKT | Promotes cancer progression | [110] |
| Bladder cancer | circ-SLC8A1 | SLC8A1 | miR-130b-3p, miR-494-3p |
Suppresses cancer progression | [111] |
| Esophageal squamous cell carcinoma | circ-VRK1 | VRK1 | miR-624-3p/ PTEN/PI3K/AKT |
Suppresses cancer progression | [112] |
| Colorectal cancer | circ-RUNX1 | RUNX1 | miR-145-5p/IGF1 | Promotes cancer progression | [45] |
| circ_0026344 | ACVRL1 | miR-183-5p | Suppresses cancer progression | [113] | |
| Gastric cancer | circ_0047905 | SERPINB5 | miR-4516, miR-1227-5p |
Promotes cancer progression | [114] |
| circ_0010882 | RPL11 | - | [115] | ||
| circ-NRIP1 | NRIP1 | miR-149-5p | [116] | ||
| circ-PSMC3 | PSMC3 | miR-296-5p | Suppresses cancer progression | [117] | |
| Pancreatic cancer | circ-BFAR | BFAR | miR-34b-5p/ MET/AKT1 |
Promotes cancer progression | [101] |
| Lung cancer | circ-BANP | BANP | miR-503-3p/LARP1 | Promotes cancer progression | [118] |
| Non-Small Cell Lung Cancer | circ-HIPK3 | HIPK3 | miR-107/BDNF | Promotes cancer progression | [119] |
| circ-GFRA1 | GFRA1 | miR-188-3p | [120] | ||
| Melanoma | circ_0001591 (circ_001436) 1 |
HIST1H2AG | miR-431-5p/ ROCK1/PI3K/AKT | Promotes cell proliferation and cancer progression | [121] |
| Multiple myeloma | circ_0007841 | SEC61A1 | miR-338-3p/BRD4 | Promotes cancer progression and cell proliferation | [122] |
1 Names in parentheses denote the circRNA ID or alias, as listed on circBase.