Skip to main content
. 2021 Jun 1;10(11):2458. doi: 10.3390/jcm10112458

Figure 3.

Figure 3

Mutational profile and MMR deficiency signatures in incident LS CRC. (A) Mutational characteristics of incident cancers (panel restricted to genes found mutant in at least one sample). Color code: orange—mutant, white—wild type, grey—n.a.; dark grey—known polymorphism, blue—variant of unknown significance; *—KRAS mutations at codons other than codon 12/13. (B) Mutation status of CRC genes in incident cancers analyzed in this study and prevalent cancers reported before [32,38] (for cohorts: red—incident CRC, blue—prevalent CRC, for genes—the same color code as in (A)). (C) Summary of the number of specific MMR deficiency-related mutations in incident LS CRC compared to prevalent LS CRC, sporadic MSI CRC and MSS CRC previously reported in Ahadova et al. [38]. (D) Comparison of the proportion of all MMR deficiency-related mutations between different CRC groups reveals a higher proportion in incident compared to prevalent tumors (100%, 95% CI: 74.85–100 vs. 75%, 95% CI: 58.7–86.4%; Fisher’s exact test, p = 0.0470). (E) Comparison of the proportion of indel mutations between different CRC groups reveals a higher proportion in incident compared to prevalent tumors (64.3%, 95% CI: 38.6–83.8 vs. 16.7%, 95% CI: 7.5–32.3%; Fisher’s exact test, p = 0.0068).