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. 2021 May 27;13(11):2625. doi: 10.3390/cancers13112625

Table 3.

The latency patterns of EBV-associated cancers.

Variable Latency I Latency II Latency III
EBER Positive Positive Positive
EBNA1 Positive Positive Positive
EBNA2 Negative Negative Positive
LMP1 Negative Positive Positive
Histological type Burkitt lymphoma
EBV+ gastric cancer
CHL (50%)
EBV+DLBCL (common)
CAEBV/HVLPD/SMBA
PEL
ENKTL
NPC
AITL
OI-LPD (common)
EBV+SMT
EBV+DLBCL (uncommon)
LYG
PAL/FA-DLBCL
PTLD
OI-LPD (uncommon)

Abbreviations: AITL, Angioimmunoblastic T-cell lymphoma; CAEBV, Chronic active HBV infection of T- and NK-cell type, systemic form; CHL, Classical Hodgkin lymphoma; EBER, EBV-encoded small RNA; EBNA, EBV-encoded nuclear antigen; EBV+DLBCL, EBV-positive diffuse large cell B-cell lymphoma, not otherwise specified (NOS); EBV+SMT, EBV-associated smooth muscle tumor; ENKTL, Extranodal NK/T-cell lymphoma, nasal type; FA-DLBCL, Fibrin-associated diffuse large cell B-cell lymphoma; HVLPD, Hydroa vacciniforme-like lymphoproliferative disorders; LMP, Late membrane protein; LYG, Lymphomatoid granulomatosis; NPC, Nasopharyngeal carcinoma; OI-LPD, Other iatrogenic lymphoproliferative disorder; PAL, Pyotholax-associated lymphoma; PEL, Primary effusion lymphoma; SMBA, severe mosquito bite allergy; PTLD, Post-transplant lymphoproliferative disorders.