Table 3.
Anticonvulsant activity and toxicity of the examined compounds 6b,j,k,n and 7c,h.
| Compound | ED50 * mg/kg (by PTZ Antagonism) |
TD50 * mg/kg | LD50 * mg/kg | TI | Latency of Convulsions Induced by TSC, min | |
|---|---|---|---|---|---|---|
| М ± м | I ** | |||||
| Control | – | – | – | 69 ± 2.0 | 1.0 | |
| 6b | 35.0 (23.0 ÷ 56.1) *** | >200 | 450 (375 ÷ 548) | 13 | 123 ± 15.2 | 1.78 |
| 6j | 35.0 (23.0 ÷ 56.7) | >200 | 580.0 (464 ÷ 725) | 17 | 90.0 ± 12.3 | 1.3 |
| 6k | 30.0 (17.6 ÷ 51.0) | >200 | 620 (504 ÷ 762.6) | 21 | 125 ± 10.8 | 1.8 |
| 6n | 41.0 (22.5 ÷ 74.6) | >200 | 930 (808.7 ÷ 1070) | 23 | 158 ± 13.5 | 2.3 |
| 7c | 42.0 (22.5 ÷ 75.1) | >200 | 890 (712 ÷ 1112.5) | 21 | 113 ± 10.1 | 1.64 |
| 7h | 30.0 (17.6 ÷ 51.0) | >200 | 680 (557 ÷ 829.6) | 23 | 116 ± 16.8 | 1.68 |
|
Ethosuximide
(200 mg/kg) |
155 (117.5 ÷ 204.5) | 520 (413÷655) | 1325 (1200 ÷ 1462) | 8.5 | 118 ± 14.0 | 1.7 |
|
Diazepam
(2 mg/kg) |
0.5 (0.4 ÷ 0.7) | 2.7 (1.4 ÷ 5.5) | 180 (128.5 ÷ 252.0) | 360 | 65 ± 3.5 | 0.9 |
* p = 0.05 at a probability level I, ** Latent period index. *** Confidence intervals ED50 are shown in parentheses.