Table 1.

Summary of thermoresponsive OEGylated poly(amino acid)s.

Entry	Polymer Structure	Amino Acids	Synthetic Method	Tcp (°C)	Secondary Structure	Ref.
1		l-Glutamic acid	ROP	x = 2, Tcp = 32 °C x = 3, Tcp = 57 °C	x = 2, 100% α-helix in freshly prepared aqueous solution x = 3, 100% helix	[34]
2		l-Cysteine	ROP	R = CH3, x = 3, Tcp = 50 °C x = 4, Tcp = 65 °C R = H, x = 3, Tcp = 51 °C	α-helix, β-sheet, and random coil	[35]
3		l-Cysteine	ROP	x = 3, Tcp = 34 °C x = 4, Tcp = 45 °C	α-helix, β-sheet, and random coil	[36]
4		l-Homocysteine	ROP	x = 4, Tcp = 40 °C	>95% α-helix	[28]
5		l-Glutamic acid	ROP	x = 4, Tcp = 25 °C x = 6, Tcp = 36 °C x = 8, Tcp = 52 °C	x = 4, 69% α-helix x = 6, 29% α-helix x = 8, 17% α-helix	[27]
6		l-Glutamic acid	ROP	x = 2, Tcp = 17 °C x = 3, Tcp = 34 °C x = 4, Tcp = 60 °C	x = 2, 69% α-helix x = 3, 37% α-helix x = 4, 30% α-helix	[27]
7		l-Glutamic acid	Post-polymerization modification	x = 2 or 3, Tcp = 22.3–74.1 °C by varying the molecular weight	100% α-helix	[37]
8		l-Glutamic acid	Post-polymerization modification	x = 3, Tcp = 45.7–51.3 °C by varying the molecular weight	78.4–100% α-helix	[38]
9		l-Glutamic acid	Post-polymerization modification	x = 3, Tcp = 44.1–62.1 °C by varying the molecular weight and monomer ratio	0–65.1% α-helix	[38]
10		l-Lysine and l-Glutamic acid	Ugi multicomponent polymerization	x = 3, Tcp = 27 °C x = 4, Tcp = 37 °C	random coil	[39]
11		Glycine	Ugi multicomponent polymerization	x = 4, Tcp = 12–17.5 °C with difference sequence	random coil	[40]