Table 2.
Genetic alterations in skull based meningiomas.
| Altered Gene | Preferential Tumor Localization | Main Histotype |
|---|---|---|
| NF2 | Posterior and lateral skull base | Fibrous, Transitional, Atypical |
| AKT1, PI3K | Anterior and middle skull base | Meningothelial |
| SMO | Olfactory groove | Meningothelial * |
| TRAF7/KLF4 | Middle skull base | Meningothelial, Secretory for co-occurring TRAF7/KLF4 |
| POL2RA | Tuberculum sellae | Meningothelial |
* SMO mutated meningiomas have significantly higher recurrence risk than AKT1 meningiomas at the same site.