Table 3.

Summary of selected published studies on conventionally fractionated radiotherapy for benign SBMs.

Authors	Patients (N)	Radiation Modality	Median Dose/ Dose per Fraction (Gy)	Median Volume (mL)	Median Follow-Up (Months)	Local Control	Late Toxicity (%)
Goldsmith et al., 1994 [79]	117	CRT	54	NA	40	89 at 5 and 77 at 10 years	3.6
Maire et al., 1995 [80]	91	CRT	52	NA	40	94	6.5
Nutting et al., 1999 [81]	82	CRT	55–60	NA	41	92 at 5 and 83 at 10 years	14
Vendrely et al., 1999 [82]	156	3D-RT	50	NA	40	79 at 5 years	11.5
Mendenhall et al., 2003 [83]	101	3D-RT	54	NA	64	95 at 5, 92 at 10 and 15 years	8
Henzel et al., 2006 [93]	84	fSRT	56	11,1	30	100	NA
Tanzler et al., 2010 [94]	144	fSRT	52.7	NA	87	97 at 5 and 95 at 10 years	7
Minniti et al., 2011 [95]	52	fSRT	50	35.4	42	93 at 5 years	5.5
Slater et al., 2012 [101]	68	Protons	56	27.6	74	99 at 5 years	9
Weber et al., 2012 [102]	24	Protons	56/1.8–2.0	21.5	62	100 at 5 years	15.5
Solda et al., 2013 [96]	222	fSRT	50/55	12	43	100 at 5 and 10 years	4.5
Combs et al., 2013 [97]	507	fSRT/IMRT	57.6/1.8–2.0	53.4	107	95.5 at 5 and 88 at 10 years	1.8
Fokas et al., 2014 [98]	253 *	fSRT	55.8/1.8–2.0	16	50	92.9 at 5 and 87.5 at 10 years	12 (G2)
Han et al., 2014 [100]	143	fSRT	50.4/1.8	11.1	32	95%	0.7
Kaul et al., 2014 [104]	136	fSRT	57/1.8–2.0	24	44.9	93.8 at 5 and 91.5 at 10 years	G1 only
Sanford et al., 2017 [103]	44	Protons	55.8–63	39.7/13.2	195	98 at 10 and 90 at 15 years	59% (≥G2)
Lillie O’steen et al., 2019 [84]	149	3D-RT	50–52/1.7–1.8	NA	144	95 at 10 and 92 at 20 years	NA

CRT, conventional radiation therapy; fSRT, fractionated stereotactic radiation therapy; IMRT, intensity modulated radiation therapy; G, grade; 3D-RT, three-dimensional conformal radiation therapy; * series including skull base and intracranial meningiomas; NA, not assessed.