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The clinical applications of aberrant ncRNA expressions in patients with RA. These aberrant ncRNA expressions can be used as the biomarkers for disease diagnosis, CV complications, and therapeutic responses. The therapeutic response biomarkers can be further divided into two groups, methotrexate (MTX) responders and TNF-α blocker responders. The increased miR-27a-3p expression is quite unique and can become a biomarker for both groups. ↑: Increase, and ↓: Decrease.
