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BTK and its interaction with reversible and irreversible inhibitors. Ten different reversible inhibitors (PDB: 3GEN, 3K54, 3PIX, 3PIZ, 4RFY, 4Z3V, 5KUP, 5T18) and irreversible inhibitors (PDB: 5P9J, 6J6M, 6OMU, 6N9P) are shown bound to a superimposed crystal structure of the BTK kinase domain. The figure focuses on the conserved (circled) and invariant water molecules at the active site.
