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. 2021 May 31;13(11):2731. doi: 10.3390/cancers13112731

Figure 1.

Figure 1

Breast cancer changes in glucose metabolic pathways and their relationship to obesity. Protein expression of 5′-AMP-activated protein kinase (AMPK, A), hexokinase 1 (HK 1, B), hexokinase 2 (HK 2, C), phosphofructokinase (PFK-1, D), glyceraldehyde-3-phosphate dehydrogenase (GAPDH, E), glucose-6-phosphate 1-dehydrogenase (G6PDH, F) and glycogen synthase kinase-3 (GSK-3 α/β, G) in benign and malignant breast tumor tissue of normal-weight (black) and overweight/obese (gray) women. The protein content is normalized to β-actin levels and expressed in arbitrary units (AU); mean values of densitometric analysis for each group are shown above respective bands. Two representative band images cut from the same blot are shown for each group (n = 9); each band is representative of three pooled samples. Images of whole uncut blots with values of densitometric analysis for each band are shown Figure S1. Bars represent average values ± S.E.M. * Comparison to respective benign counterpart, * p < 0.05, ** p < 0.01, *** p < 0.001. # Comparison to normal-weight malignant counterpart, # p < 0.05, ## p < 0.01.