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. 2021 May 28;22(11):5782. doi: 10.3390/ijms22115782

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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RNA polymerase I transcription alterations in breast cancer. (A) Heatmap analysis of components of RNA Pol I transcription at the mRNA level in TCGA breast cancer samples. Patient samples were subdivided into PAM50 subtypes. Data were derived from cbioportal (http://www.cbioportal.org/ (accessed on 1 March 2021)). (B) Breast cancer TCGA patient’ data were divided into two subgroups based on their expression patterns (whether altered or non-altered) and survival probability was plotted. (C) Kaplan–Meier survival analysis between components of RNA Pol I transcription alteration and clinical outcomes in breast cancer patients, using the KMplotter dataset (http://kmplot.com/ (accessed on 1 March 2021)). The expression pattern was stratified on relapse-free survival.