Table 8.
Summary of in vitro biochemical effects of emodin in ovarian cancer cell lines.
| Cell Line | Concentration | Mechanism | Reference |
|---|---|---|---|
| A2780 | 1 μM paclitaxel 10 μM emodin |
Down-regulation P-gp, XIAP and survivin | [35] |
| A2780 | 1 μM emodin 100 μM cisplatin |
Reduction in both intracellular platinum levels and DNA adducts | [153] |
| Sur-shRNA plasmid transfected SKOV3 and HO8910 |
60 µmol/L | Knockdown of survivin Proliferation inhibition, apoptosis induction, and reduction of invasion |
[154] |
| COC1 cisplatin-resistant COC1/DDP |
33 μM cisplatin 50 μM emodin |
Increased ROS formation Down-regulatedMRP1 gene Induction of apoptosis |
[155] |
| SK-OV-3 A2780 |
5 to 80 μM | Decreased the β-catenin, p-GSK-3β, ILK, and Slug expression Up-regulation of E-cadherin and claudin Downregulation of N-cadherin and vimentin |
[157] |
| A2780 SK-OV-3 |
20 μM | Down-regulation of the GSK-3β/-catenin/ZEB1 pathway Up-regulation of E-cadherin and keratin Down-regulation of N-cadherin, vimentin, MMP-9, and MMP-2 |
[159] |