| SMPDL3b | sphingomyelin phosphodiesterase acid-like 3b |
| LSDs | lysosomal storage disorders |
| LCB | long-chain bases |
| ER | endoplasmic reticulum |
| NADPH | nicotinamide adenine dinucleotide phosphate |
| FAD | flavin adenine dinucleotide |
| PHS | phytosphingosine |
| S1P | sphingosine-1-phosphate |
| PSLs | phosphosphingolipid |
| GSLs | glycosphingolipids |
| SM | sphingomyelin |
| C1P | ceramide-1-phosphate |
| GlcCer | glucosylceramide; glucocerebroside |
| GalCer | galactosylceramide; galactocerebroside |
| LacCer | lactosylceramide |
| Gal | galactose |
| GalNAc | N-acetylgalactosamine |
| Kdn | 2-keto-3-deoxy-nononic acid |
| Neu5Ac | N-acetylneuraminic acid |
| Neu5Gc | N-glycolylneuraminic |
| CoA | coenzyme-A |
| SPT | serine palmitoyltransferase |
| ORMDL | orosomucoid-like protein |
| KDSR | 3-ketodihydrosphingosine reductase |
| CerS | ceramide synthase |
| SMase | sphingomyelinase |
| CDase | ceramidase |
| SphK | sphingosine kinase |
| CERT | ceramide transport protein |
| SMS | sphingomyelin synthase |
| DAG | diacylglycerol |
| ERK | extracellular signal-regulated kinase |
| CERK | ceramide kinase |
| CPTP | ceramide phosphate transfer protein |
| UDP-Gal | uridine diphosphate galactose |
| UGCG | UDP-glucose ceramide glucosyltransferase |
| BMP | bis(monoacylglycerol)phosphate |
| aSMase | acid sphingomyelinase |
| L-aSMase | lysosomal acid sphingomyelinase |
| S-aSMase | secretory acid sphingomyelinase |
| nSMase | neutral sphingomyelinase |
| alkSMase | alkaline sphingomyelinase |
| NPP | nucleotide pyrophosphatase/phosphodiesterase |
| LLBP | lysosomal lipid binding proteins |
| GM2A | GM2 activator protein |
| GH | glycosyl hydrolase |
| HexA | β-hexosaminidase A |
| aCDase | acid ceramidase |
| nCDase | neutral ceramidase |
| alkCDase | alkaline ceramidase |
| LPP1-3 | lipid phosphate phosphatases |
| SPL | sphingosine-1-phosphate lyase |
| PLP | pyridoxal 5′-phosphate |
| GPCR | G-protein coupled receptor proteins |
| CT | cholera toxin |
| SV40 | simian virus 40 |
| JNK | c-Jun N-terminal kinases |
| BMDM | primary bone-marrow-derived macrophages |
| mTOR | mammalian target of rapamycin |
| GFR | growth factor receptors |
| EGFR | epidermal GFR |
| ERM | ezrin, radixin, and moesin |
| CF | cystic fibrosis |
| COPD | chronic obstructive pulmonary disease |
| SHRSP | spontaneously hypertensive stroke-prone |
| RTK | receptor tyrosine kinases |
| LT | leukotriene |
| 5-LO | 5-lipoxygenase |
| AA | arachidonic acid |
| PLA2 | phospholipase A2 activity |
| IBD | inflammatory bowel disease |
| HDAC1 | histone deacetylase 1 |
| PMA | horbol 12-myristate 13-acetate |
| EGF | epidermal growth factor |
| AD | Alzheimer’s disease |
| PD | Parkinson’s disease |
| Aβ | β-amyloid peptide |
| APP | amyloid precursor protein |
| α-syn | alpha-synuclein |
| GD | Gaucher disease |
| NPD | Niemann–Pick disease |