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. 2021 May 28;22(11):5793. doi: 10.3390/ijms22115793
SMPDL3b sphingomyelin phosphodiesterase acid-like 3b
LSDs lysosomal storage disorders
LCB long-chain bases
ER endoplasmic reticulum
NADPH nicotinamide adenine dinucleotide phosphate
FAD flavin adenine dinucleotide
PHS phytosphingosine
S1P sphingosine-1-phosphate
PSLs phosphosphingolipid
GSLs glycosphingolipids
SM sphingomyelin
C1P ceramide-1-phosphate
GlcCer glucosylceramide; glucocerebroside
GalCer galactosylceramide; galactocerebroside
LacCer lactosylceramide
Gal galactose
GalNAc N-acetylgalactosamine
Kdn 2-keto-3-deoxy-nononic acid
Neu5Ac N-acetylneuraminic acid
Neu5Gc N-glycolylneuraminic
CoA coenzyme-A
SPT serine palmitoyltransferase
ORMDL orosomucoid-like protein
KDSR 3-ketodihydrosphingosine reductase
CerS ceramide synthase
SMase sphingomyelinase
CDase ceramidase
SphK sphingosine kinase
CERT ceramide transport protein
SMS sphingomyelin synthase
DAG diacylglycerol
ERK extracellular signal-regulated kinase
CERK ceramide kinase
CPTP ceramide phosphate transfer protein
UDP-Gal uridine diphosphate galactose
UGCG UDP-glucose ceramide glucosyltransferase
BMP bis(monoacylglycerol)phosphate
aSMase acid sphingomyelinase
L-aSMase lysosomal acid sphingomyelinase
S-aSMase secretory acid sphingomyelinase
nSMase neutral sphingomyelinase
alkSMase alkaline sphingomyelinase
NPP nucleotide pyrophosphatase/phosphodiesterase
LLBP lysosomal lipid binding proteins
GM2A GM2 activator protein
GH glycosyl hydrolase
HexA β-hexosaminidase A
aCDase acid ceramidase
nCDase neutral ceramidase
alkCDase alkaline ceramidase
LPP1-3 lipid phosphate phosphatases
SPL sphingosine-1-phosphate lyase
PLP pyridoxal 5′-phosphate
GPCR G-protein coupled receptor proteins
CT cholera toxin
SV40 simian virus 40
JNK c-Jun N-terminal kinases
BMDM primary bone-marrow-derived macrophages
mTOR mammalian target of rapamycin
GFR growth factor receptors
EGFR epidermal GFR
ERM ezrin, radixin, and moesin
CF cystic fibrosis
COPD chronic obstructive pulmonary disease
SHRSP spontaneously hypertensive stroke-prone
RTK receptor tyrosine kinases
LT leukotriene
5-LO 5-lipoxygenase
AA arachidonic acid
PLA2 phospholipase A2 activity
IBD inflammatory bowel disease
HDAC1 histone deacetylase 1
PMA horbol 12-myristate 13-acetate
EGF epidermal growth factor
AD Alzheimer’s disease
PD Parkinson’s disease
β-amyloid peptide
APP amyloid precursor protein
α-syn alpha-synuclein
GD Gaucher disease
NPD Niemann–Pick disease