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Influence of haemolysis on nitric oxide (NO) bioavailability. Intravascular haemolysis induces arginase-1 and haemoglobin release. Arginase-1 produces ornithine from arginine, the required substrate for NO production. Oxygenated haemoglobin (HbO2) can scavenge NO by a dioxygenation reaction, producing inert nitrate and methemoglobin (MetHb). These two reactions decrease NO bioavailability.
