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Suppression of melanogenesis in murine B16F10 cells in the presence of 1 μM α-MSH plus 200 μM IBMX by 2a. B16F10 cells were treated with 0, 5, 10, or 20 μM of 2a for 48 h in the presence of α-MSH and IBMX. Melanin levels were measured at 405 nm. Columns represent the means±SEMs of three determinations. Data are expressed as percentages of untreated controls. ### p < 0.001, vs. untreated controls; ** p < 0.01, *** p < 0.001, versus α-MSH plus IBMX treated cells.
