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. 2021 May 25;22(11):5616. doi: 10.3390/ijms22115616

Table 3.

Inhibitory effects of urolithin derivatives 1c and 1h, o-phenylbenzyl alcohol 2a, and kojic acid on mushroom tyrosinase activity.

Compound Concentration (μM) Inhibition (%) Average of Inhibition (%) IC50 (μM)
1c 1.56 2.61 4.01 2.57 3.06 ± 0.47 18.09 ± 0.25
3.13 9.61 10.84 9.94 10.13 ± 0.37
6.25 27.31 25.08 33.10 28.50 ± 2.39
12.50 43.74 45.18 48.37 45.76 ± 1.37
25.00 60.89 61.85 60.89 61.21 ± 0.32
1h 0.78 15.68 15.61 18.94 16.74 ± 1.10 4.14 ± 0.10
1.56 28.27 24.63 31.11 28.00 ± 1.88
3.13 48.71 48.71 48.92 48.78 ± 0.07
6.25 63.98 63.95 66.79 64.91 ± 0.94
2a 1.56 0.27 0.72 1.06 0.68 ± 0.23 15.69 ± 0.40
3.13 28.06 10.29 7.03 15.13 ± 6.53
6.25 32.25 31.66 31.22 31.71 ± 0.30
12.50 55.81 50.39 54.31 53.50 ± 1.62
25.00 69.81 68.71 69.37 69.30 ± 0.32
Kojic acid 12.50 14.68 20.50 23.41 19.53 ± 2.57 48.62 ± 3.38
25.00 37.46 42.27 42.44 40.72 ± 1.63
50.00 43.81 48.83 53.08 48.57 ± 2.68