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. 2021 May 30;22(11):5878. doi: 10.3390/ijms22115878

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic of steroid metabolism in breast cancer tissue. The bioactive steroids dehydroepiandrosterone, androstenedione and estrone sulfate are formed from circulating inactive steroids by enzymes in steroid metabolism. STS, steroid sulfatase; EST, estrone sulfotransferase; 3β-HSD1, 3β-hydroxysteroid dehydrogenase type 1; 17β-HSD1, 17β-hydroxysteroid dehydrogenase type 1; 17β-HSD2, 17β-hydroxysteroid dehydrogenase type 2; 17β-HSD5, 17β-hydroxysteroid dehydrogenase type 5. Modified and redrawn according to Suzuki et al. [17].