Table 3.
Multivariable Cox analysis for incident psoriasis according to changes in proteinuria status.
| Proteinuria | Total (n) | Psoriasis (n) | IR (per 1000) | HR (95% Confidence Interval) | ||
|---|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | ||||
| Never (Neg/Neg) | 6,323,475 | 155,413 | 3.40 | 1 (ref.) | 1 (ref.) | 1 (ref.) |
| Past (Pos/Neg) | 101,698 | 2744 | 3.81 | 1.12 (1.08–1.17) | 1.06 (1.02–1.10) | 1.05 (1.01–1.09) |
| New (Neg/Pos) | 119,728 | 3186 | 3.73 | 1.10 (1.06–1.14) | 1.04 (1.01–1.08) | 1.03 (1.00–1.07) |
| Persistent (Pos/Pos) | 31,950 | 1125 | 5.10 | 1.51 (1.42–1.60) | 1.33 (1.26–1.41) | 1.32 (1.24–1.40) |
| p value | <0.0001 | <0.0001 | <0.0001 | |||
Abbreviations: Neg, no proteinuria; Pos, proteinuria present; IR, incidence rate; HR, hazard ratio; ref., reference. Model 1: non-adjusted model. Model 2: adjusted for age and sex. Model 3: adjusted for model 2 plus low income, smoking, alcohol drinking, physical activity, body mass index, hypertension, dyslipidemia, diabetes mellitus and estimated glomerular filtration rate.