Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 27;13(11):2643. doi: 10.3390/cancers13112643

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Targeting lncRNAs by RNAi, ASOs, PNAs, LNAs to knockdown and/or map lncRNAs functional domains. (A) RNA interference (RNAi) recruits the multiprotein RNAi-induced silencing complex (RISC) containing a siRNA (small interfering RNA), shRNA (short hairpin RNA) or esiRNA (endoribonuclease-prepared RNA) to specifically degrade the targeted RNA. (B) Antisense oligonucleotides (ASOs) bind to their targeted RNA, triggering endogenous RNase H1 to cleave the RNA/DNA heteroduplex. (C) Peptide Nucleic Acids (PNAs) and (D) Locked Nucleic Acids (LNAs), hybridize with complementary RNA sequences and affect activity of targeted lncRNAs. This is an original figure.