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. 2021 May 31;13(11):1827. doi: 10.3390/polym13111827

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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PAW may regulate chronic rejection-induced vasculopathy in OAT rats. Daily intake of PAW lowered the progression of vasculopathy in OAT-recipient ACI/NKyo rats by inhibiting collagen accumulation, proliferation of smooth muscle cells and fibroblasts, and T lymphocyte infiltration in the vessel wall. Moreover, the results showed reduced T and B lymphocytes, plasma cells, and macrophage activation in the spleens of the OAT-recipient ACI/NKyo rats that were administered PAW. Therefore, this study highlights the therapeutic roles of PAW and provides a more effective drug therapeutic route in vasculopathy.