Table 2.
Comparison of OAT-induced vasculopathy-related proteins in ACI//NKyo rats.
| Control ACI/NKyo (Non-OAT) |
OAT + ROW (PVG/Seac to ACI/NKyo) |
OAT + PAW (PVG/Seac to ACI/NKyo) |
||||
|---|---|---|---|---|---|---|
| baseline | 90 days | baseline | 90 days | baseline | 90 days | |
| LDH (IU/L) | 900.5 ± 99.5 | 895.9 ± 125.6 | 854.6 ± 152.5 | 1888.78 ± 323.0 a,b | 802.3 ± 152.0 | 968.8 ± 116.4 c |
| CRP (mg/dL) | 40.2 ± 13.5 | 39.6 ± 9.1 | 39.4 ± 9.8 | 163.5 ± 22.5 a,b | 26.5 ± 8.1 | 72.1 ± 5.4 a,b,c |
| HMGB1 (ng/mL) | 2.7 ± 1.4 | 2.8 ± 1.3 | 3.4 ± 1.5 | 98.7 ± 19.7 a,b | 2.5 ± 1.4 | 55.4 ± 13.1 a,b,c |
| SDF-1α (pg/mL) | 200.3 ± 22.6 | 196.5 ± 52.1 | 220.1 ± 41.5 | 432.6 ± 100.4 a,b | 241.3 ± 54.1 | 1211.4 ± 130.2 a,b,c |
| TGF-β1 (ng/mL) | 66.3 ± 21.2 | 78.9 ± 25.4 | 72.4 ± 19.7 | 378.1 ± 55.9 a,b | 72.1 ± 22.0 | 129.7 ± 54.1 a,b,c |
| INF-γ (pg/mL) | 2.5 ± 0.8 | 3.1 ± 0.9 | 1.5 ± 0.7 | 18.7 ± 5.3 a,b | 1.9 ± 0.8 | 3.5 ± 1.2 c |
| IL-2 (pg/mL) | 45.7 ± 13.5 | 56.8 ± 18.9 | 53.7 ± 21.5 | 899.4 ± 102.4 a,b | 45.2 ± 21.0 | 352.4 ± 95.7 a,b,c |
OAT, orthotopic aortic transplantation; LDH, lactic dehydrogenase; CRP, C-reactive protein; HMGB1, high mobility group box 1 protein; INF-γ, interferon γ; TGF-β1, transforming growth factor-beta 1; SDF-1α, stromal cell-derived factor 1α; IL-2, interleukin 2. Values are represented as mean ± SD. a p < 0.05 compared with baseline of the same group; b p < 0.05 compared with control ACI/NKyo (non-OAT) group at the same time point; c p < 0.05 compared with OAT + ROW (PVG/Seac to ACI/NKyo) group at the same time point. Statistical evaluations were performed using one-way ANOVA.