5-FU	5-fluorouracil
APC	Antigen presenting cell
APM	Antigen presenting machinery
B2M	β 2 microglobulin
BMMR-D	Biallelic mismatch repair deficiency syndrome
CCL	Chemokine (cc motif) ligand
cGAMP	Cyclic guanosine monophosphate-adenosine monophosphate
c-GAS	Cyclic GMP-AMP synthase
CIMP	CpG island methylator phenotype
CMS	Consensus molecular subtype
CN-LOH	Copy-neutral loss of heterozygosity
CPIs	Checkpoint inhibitors
CRC	Colorectal cancer
CSF1-R	Colony stimulating factor 1 receptor
CTLA4	Cytotoxic T-lymphocyte antigen 4
CTNNB1	β -catenin
CXC	Chemokine (cxc motif)
CXCL	Chemokine (cxc motif) ligand
DBS	Double base substitution
DC	Dendritic cell
DCR	Disease control rate
DFCI	Dana Farber Cancer Institute
DOR	Duration of response
ENPP1	Ectonucleotide pyrophosphatase/phosphodiesterase 1
ERP57	Endoplasmic reticulum protein 57
EXO 1	Exonuclease 1
FOXP 3	Forkhead box 3
FS	Frameshift
GATA3	GATA binding protein 3
GROα	Growth regulated protein α
GSK3B	Glycogen synthase kinase 3 beta
HLA	Human leukocyte antigen
HNPCC	Hereditary non-polyposis colorectal cancer
HPV	Human Papilloma Virus
ICOS	Inducible T-cell costimulator
IDO	Indoleamine 2,3-dioxygenase
IL-	Interleukin-
IL1RA	IL-1 receptor agonist
IN/DEL	Insertion/deletion
INF	Interferon
IRF3	Interferon regulatory factor 3
JAK	Janus kinases
LAG3	Lymphocyte activation gene 3
M1	M1-like macrophages
M2	M2-like macrophages
mCRC	Metastatic CRC
MDSC	Myeloid derived suppressor cells
MGMT	O6-methylguanine-DNA methyltransferase
MHC	Major histocompatibility complex
MLH1	MutL homolog 1
MMR	Mismatch repair
MMRd	Mismatch repair deficient
MMRp	Mismatch repair proficient
mPFS	Median progression free survival
MSH2	MutS homolog 2
MSH6	MutS homolog 6
MSI	Microsatellite instability
MSS	Microsatellite stable
NFKB	Nuclear factor Kappa-ligand-chain-enhancer of activated B cells
NGS	Next generation sequencing
NK	Natural killer
NKG2D	Natural killer group 2 member D
NLRC5	NLR family CARD domain containing 5
NSCLC	Non-small cell lung cancer
ORR	Objective response rate
OS	Overall survival
PD-1	Programmed cell death protein 1
PD-L1	Programmed cell death protein ligand 1
PFS	Progression free survival
PMS2	PMS1 homolog 2
POLD1	Polymerase delta 1
POLE	Polymerase epsilon
RAE1	Retinoic acid early transcript 1 ligand
RCC	Renal cell carcinoma
RFX5	Regulatory factor X5
ROS	Reactive oxygen species
RPA	Replication protein A
SBS	Single base substitution
SNVs	Single nucleotide variants
STAT	Signal transducer and activator of transcription
STING	Stimulator of interferon gene
TAM	Tumor associated macrophages
TAP	Transporter associated with antigen processing
TCF4	T cell factor 4
TCGA	The Cancer Genome Atlas
TCR	T cell receptor
Tfh	T follicular helper
TGFBR2	TGF-β receptor 2
TGF-β	Transforming growth factor β
Th1	T-helper type 1
TIM3	T-cell immunoglobulin and mucin domain-3
TMB	Tumor mutational burden
Treg	Regulatory T cells
VEGF	Vascular endothelial growth factor
VISTA	V-domain Ig suppressor of T cell activation