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Bacterial mechanisms of resistance to colistin. The different mechanisms of resistance to colistin described in Gram-negative bacilli and other bacteria are presented: the mechanism mediated by the mcr genes, those regulated by the phoP and phoQ proteins, others regulated by the pmr proteins or by the iptxT and etk genes, and operons that encode activation proteins of pmr proteins [11,30,31,32]. Generated from this work.
