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. 2021 May 31;22(11):5928. doi: 10.3390/ijms22115928

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Reduced Opa1 expression increases Bax and caspase-3 activity in Opa1^+/− mouse retinas. (A) Representative WB image shows Opa1 and Bax expression in the retinas of WT, diabetic (DM), Opa1^+/−, and diabetic Opa1^+/− (D-Opa1^+/−) mice. (B) Graphical illustration of cumulative data shows diabetes significantly downregulates Opa1 expression and that D-Opa1^+/− exhibit further decrease in Opa1 expression. Graphical illustrations of cumulative data suggest reduced Opa1 levels in D-Opa1^+/− mice promotes a diabetes-induced increase in (C) Bax levels and (D) caspase-3 activity. Data are expressed as mean ± SD. * p < 0.01, n = 6; ** p < 0.05, n = 6.