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. 2021 May 31;22(11):5928. doi: 10.3390/ijms22115928

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Reduced Opa1 expression in diabetic Opa1^+/− mouse retinas accelerates cytochrome c release. (A) Representative WB image shows cytochrome c levels in cytosolic and mitochondrial fractions in retinas of WT, diabetic (DM), Opa1^+/−, and diabetic Opa1^+/− (D-Opa1^+/−) mice. (B) Graphical illustration of cumulative data shows diabetes and reduced Opa1 level significantly upregulate cytochrome c release, and that further reduction in Opa1 expression in retinas of D-Opa1^+/− mice results in greater elevation in cytochrome c release. Data are expressed as mean ± SD. * p < 0.01, n = 6; ** p < 0.05, n = 6.