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. 2021 May 31;22(11):5928. doi: 10.3390/ijms22115928

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of diabetes or decreased Opa1 level on AC and PL development in mouse retinas. (A–D) Representative images of retinal capillaries from (A) WT, (B) DM, (C) Opa1^+/−, and (D) D-Opa1^+/− mice show an increased number of AC (blue arrows) and PL (red arrows) in the diabetic mouse retina compared with those of the control mouse retina; 40× magnification. Importantly, the number of AC and PL is increased in retinas of D-Opa1^+/− mice compared with that of diabetic mice. Graphical illustrations of cumulative data show reduced Opa1 levels in the D-Opa1^+/− mouse retina exacerbates the development of (E) AC and (F) PL. Data are expressed as mean ± SD. * = p < 0.01, n = 12; ** = p < 0.05, n = 12.