Table 3.
PFTs, 6MWT and echocardiography at follow-up after 6 months.
| All Patients (n = 18) | Type H (n = 6) | Type L (n = 12) | p-Value | |
|---|---|---|---|---|
| Pulmonary function parameters and ABGs | ||||
| TLC, % of predicted | 94 ± 11 | 92 ± 9 | 95 ± 12 | 0.62 |
| VC, % of predicted | 92 ± 16 | 95 ± 6 | 91 ± 19 | 0.92 |
| RV, % of predicted | 104 ± 24 | 93 ± 20 | 110 ± 25 | 0.27 |
| RV/TLC, % of predicted | 103 ± 22 | 96 ± 16 | 107 ± 25 | 0.42 |
| FEV1, % of predicted | 92 ± 20 | 99 ± 8 | 89 ± 23 | 0.42 |
| FEV1/FVC, % | 81 ± 9 | 84 ± 3 | 79 ± 10 | 0.06 |
| Reff, % of predicted | 84 ± 24 | 88 ± 29 | 82 ± 23 | 0.76 |
| DLCO, % of predicted | 65 ± 16 | 70 ± 9 | 62 ± 18 | 0.57 |
| DLCOc/VA, % of predicted | 81 ± 16 | 89 ± 6 | 78 ± 18 | 0.23 |
| PaO2, mmHg | 72 ± 10 | 75 ± 11 | 70 ± 10 | 0.31 |
| PaCO2, mmHg | 37 ± 4 | 38 ± 3 | 36 ± 4 | 0.31 |
| pH | 7.43 ± 0.05 | 7.42 ± 0.02 | 7.43 ± 0.06 | 0.76 |
| Base excess, mmol/l | 0.01 ± 2.60 | 0.06 ± 1.44 | −0.02 ± 3.13 | 0.55 |
| 6MWT | ||||
| Distance, m | 463 ± 134 | 438 ± 140 | 476 ± 135 | 0.81 |
| SpO2 before exercise, % | 96 ± 2 | 95 ± 2 | 97 ± 2 | 0.07 |
| SpO2 after exercise, % | 95 ± 3 | 95 ± 3 | 96 ± 3 | 0.81 |
| HR before exercise, bpm | 78 ± 15 | 85 ± 16 | 75 ± 14 | 0.28 |
| HR after exercise, bpm | 90 ± 21 | 94 ± 13 | 88 ± 25 | 0.61 |
| Dyspnea on Borg scale before exercise | 1.1 ± 1.3 | 0.4 ± 0.8 | 1.5 ± 1.4 | 0.11 |
| Dyspnea on Borg scale after exercise | 2.6 ± 2.6 | 1.1 ± 1.5 | 3.3 ± 2.8 | <0.05 |
| Fatigue on Borg scale before exercise | 1 ± 1 | 1 ± 1 | 1 ± 2 | 0.31 |
| Fatigue on Borg scale after exercise | 3 ± 2 | 2 ± 1 | 3 ± 3 | 0.92 |
| Echocardiography | ||||
| LVEF > 50%, n (%) | 18 (100) | 6 (100) | 12 (100) | 1.00 |
| Diastolic dysfunction (Grade I-IV), n (%) | 9 (50) | 3 (50) | 6 (50) | 1.00 |
| RVEF–normal, n (%) | 15 (83) | 4 (67) | 11 (92) | 0.25 |
| TAPSE, mm | 20 ± 6 | 19 ± 10 | 21 ± 4 | 0.72 |
| RVSP + CVP, mmHg | 28 ± 10 | 26 ± 9 | 30 ± 11 | 0.70 |
Values are presented as mean ± standard deviation or number of patients (percentage). ABGs = arterial blood gases; BP = blood pressure; CVP = central venous pressure; DLco = diffusing capacity for carbon monoxide; FEV1 = forced expiratory volume in 1 s; FVC = forced vital capacity; HR = heart rate; LVEF = left ventricular ejection fraction; 6MWT = six minute walk test; PaCO2 = partial pressure of carbon dioxide; PaO2 = partial pressure of oxygen; PFTs = pulmonary function tests; Reff = effective specific resistance; RV = residual volume; RVEF = right ventricular ejection fraction; RVSP = right ventricular systolic pressure; SpO2 = oxygen saturation; TAPSE = tricuspid annular plane systolic excursion; TLC = total lung capacity; VA = alveolar volume; VC = vital capacity.