Table 2.
Risk of bias assessment, first-line trials.
| Study ID | Experimental Arm | Outcome | Randomization Process | Deviations from Intended Interventions | Missing Outcome Data | Measurement of the Outcome | Selection of the Reported Result | Overall Bias |
|---|---|---|---|---|---|---|---|---|
| ATTRACTION-4 | Nivo-Chemo | OS | Low | Low | Low | Low | Low | Low |
| KEYNOTE-590 | Pembro-Chemo | OS | Low | Low | Low | Low | Low | Low |
| CheckMate 649 | Nivo-Chemo | OS | Low | Low | Low | Low | Low | Low |
| KEYNOTE-062 | arm 1 Pembro; arm2 Pembro-Chemo | OS | Low | Low | Low | Low | Low | Low |
| ATTRACTION-4 | Nivo-Chemo | PFS | Low | Low | Low | Low | Low | Low |
| KEYNOTE-590 | Pembro-Chemo | PFS | Low | Low | Low | Low | Low | Low |
| KEYNOTE-062 | arm1 Pembro; arm2 Pembro-Chemo | PFS | Low | Low | Low | Low | Low | Low |
| CheckMate 649 | Pembro-Chemo | PFS | Low | Some concerns | High | Some concerns | Low | High |
| ATTRACTION-4 | Nivo-Chemo | SAE | Low | Low | Low | Low | Low | Low |
| KEYNOTE-590 | Pembro-Chemo | SAE | Low | Low | Low | Low | Low | Low |
| KEYNOTE-062 | arm 1 Pembro; arm 2 Pembro-Chemo | SAE | Low | Low | Low | Low | Low | Low |
| CheckMate 649 | Nivo-Chemo | SAE | Low | High | High | High | Low | Low |