Table 1.
T cell subsets and their antitumor capacity. The surface markers that discriminate the different subsets, as well as the proliferation capacity and the effector functions of each population are given [143,144,145,149].
| T Cell (Memory) Subset | Surface Markers | Antitumor Functions | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| CD45RA | CD45RO | CD28 | CD27 | CD57 | CD62L | CD127 | CCR7 (CD197) |
Proliferation Potential |
Effector Functions | |
| Naïve (TNA) | + | − | + | + | − | + | + | + | +/− | − |
| Central memor (TCM) | − | + | + | + | − | + | + | + | +/− | + |
| Effector memory (TEM) | − | + | − | +/− | + | − | +/− | − | − | + |
| Resident memory (TRM) | − | + | +/− | + | − | − | + | − | ? | + |
| Memory stem cells (TSCM) |
+ | + | + | + | − | + | + | + | + | + |
| Effector memory RA cells (TEMRA) | + | + | − | − | + | − | − | − | − | + |
| Terminally differentiated effector cells (TEF) | + | − | − | − | + | − | − | − | − | ++ |