Table 4.
Correlation analysis between histological features, clinicopathological characteristics, and outcome in OSCC.
| Variable | No | Survivors | Deceased | p | |
|---|---|---|---|---|---|
| Tumor/stroma ratio | 0.0159 | ||||
| Low (≤50%) | 18 | 50% | 50% | ||
| High (>50%) | 61 | 80% | 20% | ||
| Immune infiltrate | 0.0274 | ||||
| Low | 25 | 56% | 44% | ||
| High | 54 | 81% | 19% | ||
| Tumor budding | 0.1263 | ||||
| Low (≤5) | 39 | 82% | 18% | ||
| High (>5) | 40 | 65% | 35% | ||
| Tumor necrosis | 0.2854 | ||||
| Low (≤10%) | 67 | 76% | 24% | ||
| High (>10%) | 12 | 58% | 42% | ||
| Sex | 0.1305 | ||||
| Male | 61 | 69% | 31% | ||
| Female | 18 | 89% | 11% | ||
| Smoking | 0.0269 | ||||
| Smokers | 53 | 64% | 36% | ||
| Nonsmokers | 22 | 91% | 9% | ||
| Missing | 4 | 100% | 0% | ||
| Alcohol consumption | 0.0092 | ||||
| Drinkers | 38 | 58% | 42% | ||
| Nondrinkers | 37 | 86% | 14% | ||
| Missing | 4 | 100% | 0% | ||
| T stage | 0.0035 | ||||
| T1 | 16 | 94% | 6% | ||
| T2 | 36 | 78% | 22% | ||
| T3 | 15 | 73% | 27% | ||
| T4 | 12 | 33% | 67% | ||
| Nodal status * | 0.0570 | ||||
| pN0 | 17 | 88% | 12% | ||
| pN+ | 16 | 56% | 44% | ||
| TNM stage | 0.0001 | ||||
| I | 15 | 100% | 0% | ||
| II | 29 | 90% | 10% | ||
| III | 13 | 62% | 38% | ||
| IVA | 22 | 41% | 59% | ||
| Histological differentiation | 0.1116 | ||||
| High | 17 | 88% | 12% | ||
| Intermediate | 47 | 74% | 26% | ||
| Low | 16 | 56% | 44% | ||
| Perineural invasion | 0.4430 | ||||
| Confirmed | 10 | 60% | 40% | ||
| Not confirmed | 69 | 75% | 25% | ||
| Resection margins | 0.0091 | ||||
| Positive | 9 | 33% | 67% | ||
| Negative | 70 | 79% | 21% | ||
| Locoregional recurrence | <0.0001 | ||||
| Present | 27 | 22% | 78% | ||
| Absent | 52 | 100% | 0% |
* Neck dissection was performed for 35 patients; statistical significance p < 0.05.