Table 3. Comparison of thiol/disulfide levels of the pSS patients according to xerostomia, xerophthalmia, Schirmer’s test, minor salivary gland biopsy, and some laboratory results.
Anti-SSA, anti-SS-related antigen A; Anti-SSB, anti-SS-related antigen B.
| Total thiol (µmol/L) | P-value | Native thiol (µmol/L) | P-value | Disulfide (µmol/L) | P-value | ||
|---|---|---|---|---|---|---|---|
| Xerostomia | Yes (n = 40) | 466.74 ± 35.05 | 0.341 | 437.77 ± 30.97 | 0.631 | 15.35 (0.70–217) | 0.340 |
| No (n = 28) | 474.83 ± 33.05 | 441.49 ± 31.20 | 17.70 (4.40–74) | ||||
| Xerophthalmia | Yes (n = 36) | 470.82 ± 33.10 | 0.849 | 440.82 ± 30.18 | 0.682 | 17.65 (0.70–217) | 0.970 |
| No (n = 32) | 469.22 ± 35.97 | 437.69 ± 32.04 | 16.45 (3.05–74) | ||||
| Schirmer’s test | ≤2 mm (n = 21) | 459.54 ± 36.77 | 0.090 | 433.26 ± 33.41 | 0.298 | 15.9 (0.70–74) | 0.239 |
| ≥5 mm (n = 47) | 474.77 ± 32.33 | 441.91 ± 29.75 | 17.0 (4.4–217) | ||||
| Minor salivary gland biopsy | Stage 1 (n = 4) | 488.70 ± 21.31 | 0.348 | 441.70 ± 15.89 | 0.221 | 22.37 (16.55–32.70) | 0.309 |
| Stage 2 (n = 15) | 461.90 ± 26.57 | 435.58 ± 19.68 | 13.52 (3.10–74) | ||||
| Stage 3 (n = 26) | 475.15 ± 34.71 | 442.88 ± 34.24 | 17.7 (3.05–27.60) | ||||
| Stage 4 (n = 23) | 468.18 ± 38.38 | 437.17 ± 35.17 | 17.0 (0.70–217) | ||||
| Anti-SSA | Negative (n = 29) | 476.50 ± 36.09 | 0.184 | 443.84 ± 30.71 | 0.299 | 17.8 (0.70–74) | 0.324 |
| Positive (n = 39) | 465.29 ± 32.43 | 435.88 ± 30.98 | 13.97 (3.05–217) | ||||
| Anti-SSB | Negative (n = 21) | 479.84 ± 32.92 | 0.116 | 447.54 ± 24.51 | 0.143 | 18.1 (3.05–74) | 0.421 |
| Positive (n = 47) | 465.70 ± 34.24 | 435.57 ± 32.96 | 14.75 (0.70–217) | ||||