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(A) Structures and antifungal activity of selective Mycobacterial ClpP1P2 inhibitors 1 (Bortezomib) and 32. (A series of dipeptidyl boronates with variation at the P1, P2, and X side-chains were synthesized); (B) ClpP1P2 inhibition assay; (C) Proteasome inhibition assay; (D) Docking of 1 into Mtb ClpP1P2; (E) Docking of 37a into Mtb ClpP1P2; (F) Structures and antifungal activity of selective Mycobacterial ClpP1P2 inhibitors 33–37a (Adapted from [59,62]).
