Mycobacterium tuberculosis
|
Mtb
|
H. proteasome |
Human proteasome |
MIC |
Minimum inhibitory concentration |
ACT |
Artemisinin-based combination therapies |
aaRSAmino |
Acyl tRNA synthetase |
CQ |
Chloroquine |
ADME |
Absorption, distribution, metabolism, and excretion |
SsrA-tagged protein |
Caseinolytic-protease-specific degradation protein |
RLU |
Relative luminescence |
WT cell lines |
Wild-type cell lines |
aaRS |
Aminoacyl-tRNA synthetase |
ClpP |
Caseinolytic proteases |
TB |
Tuberculosis |
Chloromethyl ketones |
CMKs |
enoyl- reductase |
ENR |
Enoyl-[acyl-carrier-protein] reductase [NADH] |
InhA |
Nicotinamide adenine dinucleotide oxidized |
NAD+ |
Nicotinamide adenine dinucleotide reduced |
NADH |
artemisinin-based combination therapies |
ACT |
Plasmodium Falciparum
|
P. Falciparum
|
Plasmodium falciparum 3D7
|
CQ-sensitive 3D7 |
structure−activity relationship studies |
SARs |
3D7 |
Chloroquine (CQ) sensitive P. falciparum strain |
W2 |
Chloroquine (CQ) resistant P. falciparum strain |
D2d |
Chloroquine (CQ) resistant P. falciparum strain |
half-life |
t1/2 |
availability |
F |
WT cells |
Wild-type cells |