Table 2.

Metabolite univariate analysis for the comparison between eCRC and mCRC patients.

Metabolite	p-Value	p-Value FDR Adjusted	Effect Size
Glutamine	0.0002	0.007	0.330
Histidine	0.002	0.028	0.280
Formate	0.018	0.194	−0.212
Alanine	0.061	0.320	0.168
Proline	0.062	0.320	0.168
Valine	0.069	0.320	0.163
3-methyl-2-oxovalerate	0.070	0.320	−0.163
Tyrosine	0.122	0.451	0.139
Acetate	0.127	0.451	−0.137
Glucose	0.161	0.514	0.126
Isoleucine	0.193	0.561	0.117
3-hydroxybutyrate	0.234	0.619	−0.107
Leucine	0.251	0.619	0.103
Glycoproteins	0.281	0.637	0.097
Lactate	0.299	0.637	−0.093
Lipoproteins βCH2	0.403	0.752	0.075
Lipoproteins N(CH3)3	0.417	0.752	0.073
cholesterol	0.434	0.752	0.070
Creatinine	0.447	0.752	0.068
Citrate	0.472	0.755	0.065
Lipoproteins CHCH	0.572	0.833	0.051
Glutamate	0.614	0.833	−0.045
Lipoproteins CH2n	0.618	0.833	0.045
N,N-Dimethylglycine	0.625	0.833	−0.044
Lipoproteins CHCH2CH	0.661	0.846	0.039
Lipoproteins CH3	0.698	0.859	0.035
Pyruvate	0.760	0.901	−0.028
Phenylalanine	0.792	0.905	−0.024
Dimethylsulfone	0.846	0.911	−0.018
Glycine	0.896	0.911	−0.012
Lipoproteins CHCH2CH2	0.898	0.911	0.012
Creatine	0.911	0.911	−0.010

p-value, p-value adjusted for multiple comparisons, and Cliff’s Delta effect size are reported in table for each metabolite. An adjusted p-value < 0.05 is considered statistically significant. Positive effect size means lower levels in mCRC serum samples.