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. 2021 Jun 2;26(11):3348. doi: 10.3390/molecules26113348

Table 1.

Pharmacological agents which have potential effects on ASD and neurodevelopmental disorders treatment.

Names Structures Targets Effects
8-OH DPAT graphic file with name molecules-26-03348-i001.jpg 5-HT1AR/5-HT7R agonist decreased mGluR-mediated LTD, prevented internalization of AMPA receptors [43]; normalization of respiratory function [77]
(+)-5-FPT graphic file with name molecules-26-03348-i002.jpg 5-HT1AR/5-HT2CR/5-HT7R agonist reduction of stereotypic behavior, social activity increase [65]; reduced the number of audiogenic seizures [78]
aripiprazole graphic file with name molecules-26-03348-i003.jpg partial 5-HT1AR/ HT2AR/5-HT2CR/5-HT7R/D1R/D2R/D3R/D4R/D5R agonist; 5-HT1BR/5-HT1DR/5-HT2AR/5-HT2CR/5-HT3AR/HT6R/5-HT7R/D1R/D2R/D3R/ D4R/D5R/some alpha adrenergic and histamine receptors antagonist irritability amelioration [14,15,66]
risperidone graphic file with name molecules-26-03348-i004.jpg 5-HT1A/5-HT1DR/5-HT2AR/5-HT2CR/5-HT7R/D1R/D2R/some alpha adrenergenic and histamine receptors antagonist irritability and aggressive behavior amelioration [17,18,66]
lurasidone graphic file with name molecules-26-03348-i005.jpg 5-HT1AR/5-HT2AR/5-HT7/D2R/ some alpha adrenergic receptors antagonist; 5-HT1AR partial agonist irritability and aggressive behavior amelioration [19,66]
1 graphic file with name molecules-26-03348-i006.jpg 5-HT1AR/5-HT7R agonist metabolically stable and have suitable CNS druglike properties [67]
2 graphic file with name molecules-26-03348-i007.jpg 5-HT1AR/5-HT7R agonist metabolically stable and have suitable CNS druglike properties [67]
3 graphic file with name molecules-26-03348-i008.jpg 5-HT1AR/5-HT7R agonist; 5-HT2BR antagonist metabolically stable and have suitable CNS druglike properties [67]
LP-211 graphic file with name molecules-26-03348-i009.jpg 5-HT7R agonist; affinity to 5-HT1AR/D2R neurite growth promotion (increased the number of dendritic spines and synaptic connections) [54,68,69]; decreased mGluR-mediated LTD, prevented internalization of AMPA receptors [43,44]; reduction of stereotypic behavior, improvement of recognition memory [38,39]; anxiety alleviation, exploratory behavior and learning ability improvement [38,39]; normalization of mitochondrial ETC function [40,41]