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. 2021 Jun 2;26(11):3353. doi: 10.3390/molecules26113353

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Protective activities of fisetin against PD-associated cellular pathologies. (a) Fisetin preincubation reduced oxidative stress-induced cell death in SH-SY-5Y cells caused by t-BHP lesion. (b) Fisetin preincubation protects cells from the dopaminergic injury caused by MPP+ with reduction of DAT and TH and an increase of SNCA mRNA expression levels. (c) Fisetin modulates human αsyn aggregation in a yeast model of PD. Fisetin reduces αsyn–GFP toxicity in yeast cells by decreasing the number of inclusions per cell, having these inclusions an increased area) and a predominant localization within the cytoplasm. Green arrows indicate fisetin effects in the different models.