Table 2.

Sacran activity testing in biomedical fields.

Application in Biomedical Fields	Testing Object	Test Type	Ref.
Cancer Delivery	Polyamidoamine conjugates alpha-cyclodextrin and phosphate-polyethylene glycol with low-molecular-weight sacran for selective siRNA delivery	In Vitro and In Vivo	[56,57]
Wound Dress	Sacran hydrogel	In Vitro and In Vivo	[23,58,59]
	$\gamma$-Cyclodextrin addition to sacran hydrogel film	In Vitro and In Vivo	[58]
	Curcumin addition to 2-hydroxypropil-$\gamma$-cyclodextrin on hydrogel film	In Vitro and In Vivo	[60]
	Sacran hydrogel film with keratinocyte growth factor	In Vitro	[39]
	Epidermal growth factor (EGF) in sacran hydrogel film as the increased fibroblast migration	In Vitro	[61]
	HP-βCD complex in freeze dried Sac/SDACNF	In Vivo	[62]
Anti-allergy	Topical sacran in mouse model induced by 2,4-dinitro-1-fluorobenzene	In Vivo	[63]
	Topical sacran in mouse model induced by DME-	In Vivo	[64,65]
	Topical sacran for atopic dermatitis	In Vivo	[66]
Anti-inflammation	Sacran for atopic dermatitis in mouse induced by 2,4-dinitro-1-fluorobenzene	In Vivo	[67,68]
	Sacran for atopic dermatitis in mouse induced by 2,4-dinitro-6-fluorobenzene	In Vivo	[44]
	Sacran and carrageenan induced in TPA-induced mouse ear	In Vivo	[33]
Others	Effectiveness of sacran on air pollution	In Vitro	[69]
	Effectiveness of sacran to prevent skin evaporation	In Vitro	[70]
	Improve the maturation of corneocytes	Clinical study	[27,71]
	Genetic engineering	In Vitro	[37,72]