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Phosphomimetic mutation of a potential ROK target site induces nuclear localization of MRTF. LLC-K1 proximal tubular cells were transfected with Hemagglutinin (HA)-tagged WT or T82D mutant MRTF-B constructs. Cells were stained for the HA epitope and nuclear marker, DAPI. Note that WT MRTF is cytosolic whereas the T82D mutant shows robust nuclear accumulation. Bar: 20 µm. (P. Speight and & A. Kapus, unpublished).
