Table 2.
Transcription factors and transcriptional co-factors interacting with MRTF.
| Transcription Factor | Domain Bound | Effect on MRTF Localization/Stability | Effect on MRTF Transcriptional Activity | Reference |
|---|---|---|---|---|
| SRF | B1/Q | N/D | + | [37] |
| FHL2 | N-term (RPEL/B1-3/Q) | Increased myocardin protein levels | + | [60,61] |
| N-term (RPEL/B1-3/Q) | Increased MRTF-A protein levels | + | ||
| B1/Q | Decreased MRTF-B nuclear localization | − | ||
| YAP/TAZ | C-term (PPxY) | Decreased MRTF nuclear accumulation | −/+ | [22] |
| Smad3 | B1 | Promotes MRTF degradation | non-CArg = +; CArG = − | [19,20] |
| SP1 | N/D | N/D | + | [62] |
| NFκB/p65 | B1/Q | N/D | −/+ | [63,64] |
| Stat5 | Q | N/D | non-CArG/ICAM-1 = + | [65] |
| Stat3 | N/D | N/D | + | [66] |
N/D, Not Determined; − or + notes if the molecule effects MRTF transcriptional activity negatively or positively.