Table 3.
Diagnostic performance of the 13C-UBT and 14C-UBT with optimal cutoff values for H. pylori positivity
| Method | Histology | Sens (%) | Spec (%) | Acc (%) | FPR (%) | FNR (%) | ||
|---|---|---|---|---|---|---|---|---|
| + | – | 95%CI | 95%CI | 95%CI | 95%CI | 95%CI | ||
| 13C-UBT | + | 120 | 14 | 83.9 | 81.1 | 82.9 | 18.9 | 16.1 |
| – | 23 | 60 | 76.6–89.3 | 70.0–88.9 | 77.4–87.4 | 11.1–30.0 | 10.7–23.4 | |
| 14C-UBT | + | 158 | 12 | 82.3 | 84 | 82.8 | 16 | 17.7 |
| – | 34 | 63 | 76.0–87.3 | 73.3–91.1 | 77.8–86.9 | 8.9–26.7 | 12.7–24.0 | |
Based on the maximum Youden index method, the optimal cutoff values for H. pylori positivity were 10.4% DOB and 238 DPM for the 13C-UBT and 14C-UBT, respectively
UBT urea breath test, Sens sensitivity, Spec specificity, Acc accuracy, FPR false positive rate, FNR false negative rate, CI confidence interval